At a molecular level, L-theanine is structurally remarkably similar to L-glutamate and L-glutamine, which are the primary excitatory neurotransmitters in the human brain
This process may initiate the inappropriate incorporation of selenocysteine (SeCys) and selenomethionine (SeMet) into proteins, as well as impair their function, which may in turn lead to the development of oxidative stress, i.e., a state in which the oxidizing potential increases to the level that threatens the stability of cellular structures [14]
Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB
The CREDENCE, DAPA-CKD, and EMPA-KIDNEY trials showed that canagliflozin, dapagliflozin, and empagliflozin, respectively, are associated with a reduction in the composite outcome of death from renal or CV causes, end-stage renal disease, or worsening of serum creatinine or eGFR [[68-70]
Constipation and altered bowel patterns may require two to four weeks to normalize after discontinuation