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Among the most promising therapeutic approaches, much research interest has been devoted to catalytic metal-based anticancer agents that could convert natural biomolecules into (cytotoxic) products or products that ultimately lead to cell death

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With a genetic disease like autism, theres the concept of a double hit. You might have a gene mutation that gets you close to the threshold for autism, and then you experience another insult (medical event or environmental exposure) that confounds it and pushes you over the line