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[138] Further investigation into CV and renal benefits is underway, particularly concerning heart failure and chronic kidney disease, with ongoing research assessing whether these benefits extend to nondiabetic populations

A 2026 BMJ systematic review also found weight regain after cessation of weight-management medications

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For instance, the co-administration of tanshinone and polyphenol extract contributed to an increase in the area under the plasma concentration-time curve and a decrease in the total plasma clearance of SalB (Guo et al., 2008)