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EM density map and model are shown for all seven transmembrane helices and H8 of the receptor, the ExP5 peptide and the 5 helix of the GS Ras-like domain

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Semaglutide: GLP-1liraglutide(Saxenda)Semaglutide(Wegovy)12 (1218BMI30kg/m2)60kg 3.0mg12 (BMI)4% 2.4 mg 12 (BMI) 5% 2023 GLP-112 611Liraglutide20249NEJM 5646%BMI5.8%1.6%P 27 GLP-1 GLP-1 A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity N Engl J Med 2020

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