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As shown in the pre-treatment AUC data ( Figure S4A , C , Method S3 ), all groups demonstrated elevated blood glucose excursions, consistent with impaired glucose tolerance

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Retatrutide : Currently in Phase 3 trials, this triple agonist (GLP-1, GIP, and glucagon receptors) has shown 24.2% average weight loss in a Phase 2 study

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Often referred to as GLP-3 (RT) because of its triple-action approach, Retatrutide works differently than traditional GLP-1 therapies by interacting with three key metabolic pathways involved in appetite regulation, energy balance, and metabolism