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However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)

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The dosage must be taken once daily in the fasted state with minimal liquid and at a substantially higher dose than the approved once-weekly injectable formulation ( 12, 13 )

The phenotype of such a MASLD animal model is closer to that of human MASLD and the experimental results are more applicable to humans