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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

There is a randomized, placebo-controlled trial of the finished product in healthy adults

Another exciting feature of MariTide is its long-acting formulation, which requires only one injection per month, making it more convenient than current once-weekly options

10.1016/j.cmet.2019.01.020 Summary Keywords xCT transporter, cysteine, lipid peroxides, glutathione, ferroptosis, tumor-resistance Citation Daher B, Vueti M and Pouyssgur J (2020) Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

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