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a RLM (1D): RLM incubation without fractionation, RLM (2D): RLM incubation with fractionation, 3A4 (1D): CYP3A4 Supersome incubation without fractionation, 3A4 (2D): CYP3A4 Supersome incubation with fractionation, DDA: confirmed by DDA, MRM: confirmed by MRM

It was shown that HB acts in vitro as a neuroprotective agent against the toxicity of MPTP, which induces a defect in the mitochondrial complex I of dopaminergic neurons (157)

Lancet 2004;364:1789-1799 Kennedy S, Bergqvist A, Charon C, et al

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GLP-1 receptor agonists were originally developed for the treatment of type 2 diabetes mellitus, and they are now among the pharmacological agents with therapeutic indications not only in adults but also in pediatric and adolescent populations