11,190,192,193 To note, real world observational data suggest that average weight loss is lower than that seen in randomised controlled trials due to a combination of lower achieved dosages, treatment interruptions and high discontinuation rates (up to 2050% within the first year)
Ales Z, Zeman M, Slaby A, Vecka M
In a parallel matched cohort of 37,740 patients with both IBD and T2D, GLP-1 RA users had a 5-year colorectal cancer incidence of 0.31% vs 0.57% in non-users (OR, 0.54), representing a 46% reduction in odds
The men who achieve lasting results treat GLP-1 therapy as one component of a broader lifestyle overhaul, not a magic solution that works while they continue eating fast food and skipping the gym
Some compounded semaglutide also comes in prefilled syringes or pens from the pharmacy