In hypertensive rat models, chronic administration of quercetin, puerarin, or rutin leads to lowered blood pressure, associated with improved endothelial function and decreased oxidative stress markers (Zheng et al., 2024
MASH (metabolic dysfunction-associated steatohepatitis, formerly NASH) covered under standard Part D pathways
Food and Drug Administration cleared Ascletis Pharma to start a Phase 1 clinical trial of ASC35 , a once-monthly subcutaneous peptide that activates both the GLP-1 and GIP receptors
Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, glucagon) that remains unlicensed in the UK, with no MHRA approval, no NHS availability, and no BNF listing as of 20242025
While typically mild and transient, injection site discomfort can impact treatment adherence and patient experience