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Hexarelin GHSR-1a Gq/11 PLC- IP3 Intracellular Ca Rapid GH vesicle exocytosis This calcium-mediated pathway produces a sharper, more intense GH spike compared to the cAMP-mediated signaling of GHRH analogs

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In contrast, lower baseline limbic CBF levels were significantly linked to greater CAPS score improvement ( = 0.342, P = 0.007)