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GHK-Cus mechanism depends on gradual tissue accumulation over the cycle, not on high single-day concentrations

(101(2)):297-317 doi:10.1016/j.mcna.2016.09.013

It is a chemical inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which catalyzes the methylation of nicotinamide using S-adenosylmethionine as the methyl donor