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The present inventors when carried out the reaction of (3-31) amino acid fragment of Semaglutide having the amino acid sequence Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser- Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly with PGi-His(PG)-Aib-OH and further converted the obtained compound to Semaglutide surprisingly found that the said process efficiently controlled the formation of D-His, Des- His, Des-Aib, Di-Aib, Des-Aib-His impurities in the Semaglutide API which is highly advantageous on industrial scale especially for complex peptide molecules like Semaglutide

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The medication is prescribed by US-based clinicians after an online consultation process

(4)(5) The difference in their mode of action is the pathway by which they exert their action