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1 nowadays, it necessarily makes a distinction between good stress, in which the increase in specific ROS concentrations induces an adaptive response known as oxidative eustress, and bad stress, known as oxidative distress, in which higher ROS concentration triggers aberrant and unspecific target oxidations, disrupting cell homeostasis (Aparicio-Trejo et al

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Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis