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Metformin is a first-line drug for treating type 2 diabetes associated with AMPK activation

There are specific nutrients that support the entirety of this system, including normal immunity (defense mechanisms), inflammatory responses, and oxidative stress responses

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A phase 2B trial (NCT02279524) showed that although aramchol 600 mg had no impact on liver fat fraction, it provided favorable outcomes in liver fibrosis and ALT levels, suggesting it may be a promising therapy for MASH with fibrosis