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Acknowledgments The authors acknowledge the Department of Pharmaceutical and Medical Equipment, Bayi Orthopaedic Hospital, and the Department of Paediatrics, Sichuan Academy of Medical Science and Sichuan Provincial Peoples Hospital, for supporting our work

Dietary sources of vitamin B12 include: Meat and poultry: Beef, lamb, pork, and chicken are excellent sources Fish and seafood: Particularly salmon, trout, tuna, and shellfish Dairy products: Milk, cheese, and yoghurt provide readily absorbed B12 Eggs: Especially the yolk Fortified foods: Many breakfast cereals, plant-based milk alternatives, and nutritional yeast are fortified with B12 For vegans and vegetarians , who are at increased risk of deficiency, the Vegan Society and British Dietetic Association recommend: Regular consumption of fortified foods (at least three servings daily) Consideration of B12 supplements (typically 10 micrograms daily or 2000 micrograms weekly) Monitoring of B12 status as advised by a healthcare professional based on individual risk Supporting overall hair health involves a holistic approach: Maintaining a balanced diet rich in protein, iron, zinc, and biotin Ensuring adequate hydration Managing stress, which can affect hair growth cycles Avoiding harsh chemical treatments and excessive heat styling Protecting hair from environmental damage When to seek medical advice: If you follow a vegan diet and have not arranged B12 supplementation If you have conditions affecting nutrient absorption (coeliac disease, Crohn's disease, previous gastric surgery) If you take medications that may interfere with B12 absorption long-term If you experience symptoms suggestive of deficiency It is important to recognise that whilst optimising B12 status supports overall health, supplementation will not reverse age-related greying in most cases

doi: 10.1073/pnas.1609246113 225 WolinskyJ

Pair with black pepper extract (BioPerine)already included in quality formulas

Premature graying in white people can start as early as 20 years old, while a person can be as young as 25 years old among Asian people and 30 years old in African-American populations, according to a 2013 study