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Conversely, by "cognitive dysfunction" we mean the loss of such abilities

A study indicates that 6% to 15% of opioid-nave post-op patients became chronic opioid users after major or minor surgery, including 4% of those who underwent total hip arthroplasty and 8% of total knee arthroplasty

This is consistent with the theory of local area network inhibition, which posits that excessive or unstable excitatory activity can induce homeostatic over-inhibition, thereby contributing to clinical symptomswhose precise manifestations depend on the neural networks involved

(Left: Proportion of studies with low, or high, or unclear concerns regarding applicability