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The two practical considerations are gastric emptying, which is strongest when you start and after each dose increase, and weight loss, which reduces your levothyroxine requirement

The gap between the nominal patent expiration date and actual generic entry which can span anywhere from zero to six-plus years depending on litigation outcomes is where most of the analytical uncertainty lives

In choosing the most appropriate obesity treatment, it is important to consider potential side effects, tolerability, contraindications, drug interactions, method of administration and cost

Lau J, Bloch P, Schaffer L, Pettersson I, Spetzler J, et al