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Furthermore, LOx-catalyzed lactate depletion activates CRISPR/Cas9-mediated SIRP genome-editing plasmids, which, when combined with a MOF, are used to promote the conversion of M2 macrophages to M1 macrophages in the breast cancer TME, thereby hinting the therapeutic effect of CRISPR/Cas9-mediated genome-editing

European journal of clinical nutrition, 69(1), 1-2.