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4 Zeisel SH, da Costa KA Choline: an essential nutrient for public health (Nutr Rev, 2009)Review establishing that choline deficiency causes hepatic fat accumulation and liver injury, and that repletion reverses deficiency-related steatosis

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In the GHK-Cu complex, the copper ion coordinates with multiple binding sites: the nitrogen from the histidine imidazole side chain, the alpha-amino group of glycine, the deprotonated amide nitrogen of the glycine-histidine peptide bond, and oxygen from the lysine carboxyl group, forming a square-planar pyramid configuration

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The dynamic nature of ECD observed in this study is consistent with previous findings that GLP-1R is equipped with high versatility to recognize a wide range of ligands with distinct chemotypes 40,41 and to participate in diversified receptor activation processes 13,34 (Supplementary Fig