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A multifaceted, chronic disease may need a multi-pronged, long-term, sustainable intervention, added Jaisinghani

Eli Lilly is still in the middle of phase three clinical trials on its oral drug, orforglipron, meaning it's likely to hit the market later

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown promise in preclinical models of neurodegeneration, with emerging evidence suggesting these effects may be driven by modulation of neuroinflammation

Effects on the Brain and Circadian Rhythm GLP-1 receptors are present in parts of the brain that regulate: Sleep-wake cycles Hormone release Stress response Energy balance When semaglutide activates these pathways, the body may temporarily adjust its sleep rhythm