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The StatinGLP-1 Problem: The Gut Fix Nobodys Talking About Statins, the most prescribed drug in the world, may quietly disrupt metabolic pathways

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Among the series of analogues, including GLP-1 (137), GLP-1 (637), GLP-1 (737), GLP-1 (837), etc., only those which start with His 7 retain their insulinotropic activity.11 GLP-1R Arg 299 and Trp 306 may interact with GLP-1 His 7 .12 Replacement of GLP-1 His 7 with Phe 7 does not influence either its receptor affinity or cAMP activity, indicating that the aromaticity of His is crucial to its activity