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The addition of B12 does not boost weight loss, but may help combat the side effects of semaglutide, such as lethargy and dizziness, by promoting metabolism and increasing the availability of usable energy

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References Deanfield, John et al., Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial, The Lancet, Published on October 22, 2025, DOI: 10.1016/S0140-6736(25)01375-3 Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT), ClinicalTrials.gov ID NCT03574597,