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It represents the primary cause of pain, functional impairment, and long-term disability among middle-aged and elderly individuals globally ( Photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), has demonstrated unique potential as a non-pharmacological, extracorporeal photobiomodulation (PBM) treatment modality in the management of KOA ( Nevertheless, the clinical application of PBMT in KOA remains controversial, with its heterogeneous efficacy drawing considerable attention