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Treatment with FOXO4-DRI reduces hydroxyproline content in lung tissue, a direct measure of collagen deposition, and improves lung histology assessed by hematoxylin-eosin and Masson trichrome staining

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Growth hormone is secreted from the pituitary gland and stimulates IGF-I synthesis and secretion, which in turn inhibits GH secretion via the negative feedback loop (3)

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