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Key molecular properties used for mapping include molecular weight, lipophilicity (logP and logD), topological polar surface area (TPSA), and hydrogen-bond dynamics

Early intervention, proper footwear, and non-invasive treatments like physiotherapy and osteopathy can help manage symptoms effectively

Women using oral contraceptives should use a non-oral method or add a backup method for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase due to potential reduced contraceptive effectiveness