The pertinent findings of this study are: 1) enhanced hepatic de novo serine synthesis is required for SAAR to improve glucose tolerance, 2) concurrent with transcriptional activation, a serine synthesis-GSH-lysine lactoylation feedback loop may underlie the increased hepatic serine synthesis in response to SAAR, and 3) hepatic serine synthesis is not necessary for the SAAR-mediated decline in adiposity and liver triglycerides
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Review Article | DOI: Cagrilintide Combined with Semaglutide: A New Approach for Treatment of Obesity and Type 2 Diabetes Endocrinology Division, Department of Medicine Olive View-UCLA Medical Center, David-Geffen UCLA Medical School, CA, USA
