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Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118

The paper, A review of vitamin D and Parkinsons disease, appeared in Elseviers Maturitas , which is the official journal of the European Menopause and Andropause Society

For instance, the authors found that the SLC25A1-SLC25A4 mitochondrial transporter interactome was linked to 22q11.2 gene defect

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