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A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells

Its amino acid sequence is Gly-Glu-Pro-Pro- Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

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These results highlight hepsin's crucial role in controlling APAP-induced liver toxicity by regulating the cellular abundance of GJ proteins, which can affect the transmission of toxic metabolites or cell death signals and potentially increase oxidative stress

Phospholipids (e.g., phosphatidylcholine) also support cell membrane repair