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Additionally, people with type 2 diabetes may experience stomach pain related to medications used to manage their condition, concurrent gastrointestinal disorders, or complications arising from poor glycaemic control

Other consumer advocates, such as Public Citizen, have called on the agency to require full approval, not a more lenient workaround

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The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

Cairo Univ., Vol