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A 2019 global survey highlighted marked geographic disparities, with the highest prevalence reported in countries such as Italy, Japan, and New Zealand, and the lowest in Bosnia, Albania, and North Macedonia ( PCOS is among the most prevalent endocrine disorders in women, affecting approximately 813% of women of reproductive age worldwide ( 4 Pathobiology of PCOS PCOS is a complex, multifactorial endocrine disorder in women, arising from the interplay of genetic susceptibility, environmental exposures, and modifiable lifestyle factors such as diet and physical activity

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Notably, 50% of measured NADP + in frozen blood originated from NADPH, allowing for extrapolation of NADPH and NADP + levels before freezing, if fresh sample analysis is not feasible

Gentle swirling is always the preferred method