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Data Availability Statement All source data for this work (or generated in this study) are available upon reasonable request.

The selection of an efficient extraction method depends on various aspects, including the chemical structure of the target polyphenols, the samples particle size, and the existence of other coexisting chemicals that may interfere or interact during the extraction process (33)

doi: 10.1016/j.phrs.2022.106563 71 CoutinhoLLJuniorTCTRangelMC

Epidemiology 21 , 6269 (2010)

The reaction catalyzed by GTP cyclohydrolase 1 (GTPCH) is considered the rate-limiting and committed reaction of BH 4 synthesis