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Adjusting protocols based on results When to extend protocol Extend if : Making progress but not complete (60-70% healed, goal is 90%) Results plateaued but could improve with more time No side effects, tolerating well Can afford extension How to extend : Add 4-8 weeks to original timeline May need to order more supplies Continue same doses unless adjusting Example : Planned 8 weeks BPC-157 , at week 8 injury 70% healed

of the CY 2025 OPPS/ASC proposed rule, we proposed that the OPPS payment rates used for ratesetting under the ASC payment system for CY 2026 and subsequent years would not incorporate the prospective offset to the OPPS conversion factor, as a result of the 340B remedy offset

Kato-Kataoka, A., Sakai, M., Ebina, R., Nonaka, C., Asano, T., & Miyamori, T

Desired Concerns: The concerns that are to be addressed play a major role in evaluating the cost