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Dosing is titrated to achieve optimal IGF1 and cortisol patterns without dependency or adverse effects

8 weeks (2 vials): ~6 mL 1 bottle 16 weeks (3 vials): ~9 mL 1 bottle Alcohol Swabs One for the vial stopper + one for the injection site each day

A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

2.3 Fatigue score measurement During the clinical visits, the treating physician recorded the fatigue level using Question 1 adapted from the Bristol rheumatoid arthritis fatigue numerical rating scale (BRAF-NRS) (37)

The GCLM subunit has no enzymatic activity but has an important regulatory function increasing the efficiency of the GCLC subunit