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Folate and vitamin B12 are vital cofactors working with enzymes in the methylation cycle

You can contact the Parliamentary and Health Service Ombudsman (PHSO) which makes final decisions on unresolved complaints about the NHS in England

Before starting, confirm with your healthcare provider that self-administration is appropriate for you

Materials and methods Chemicals and materials Analytical standards of CNCbl, OHCblHCl, AdoCbl, and MeCbl were obtained from Sigma-Aldrich (Steinheim, Germany)

Cyanocobalamin poses additional risks to smokers, and to individuals with methylation, liver or kidney issues, as these conditions can make it difficult to eliminate cyanide