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Reading Across From GLP-1 Receptor Agonists in PCOS If retatrutide itself has never been studied in PCOS, the closest available analog is the GLP-1 receptor agonist class liraglutide, semaglutide, exenatide, and dulaglutide which shares retatrutides central appetite-suppressing, incretin-based mechanism (retatrutide simply adds GIP and glucagon arms on top)

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In either case, the pen must be discarded 6 weeks after first use