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Important considerations include: Potential interactions with hormonal contraceptives (particularly with tirzepatide and exenatide) Pregnancy planning (GLP-1 medications require discontinuation before conceptiontypically 2 months for semaglutide and 1 month for tirzepatide) Management of gastrointestinal side effects that might overlap with endometriosis symptoms Some hormonal therapies for endometriosis can affect weight, and addressing metabolic health may be a separate but important consideration

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Some appetite changes may appear within the first few weeks, but visible weight loss usually builds over several months

Structurally modified to reduce binding to IGF-binding proteins, IGF-1 LR3 may remain bioactive significantly longer than unmodified IGF-1 under experimental conditions, allowing for sustained receptor engagement and downstream pathway analysis

There is no single "semaglutide diet," but general healthy eating principles are strongly recommended