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Reductive carboxylation A process that occurs in some normal and cancer cells whereby -ketoglutarate proceeds 'backwards' through the tricarboxylic acid cycle, being reduced through the consumption of NADPH by isocitrate dehydrogenase in the non-canonical reverse reaction to form citrate

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doi: 10.3390/medicina61010017

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1 O - Singlet oxygen

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Meanwhile, SCFAs also suppresses STAT 3 phosphorylation and effectively reduces IL-6/IL-21-mediated Th 17 polarization (Anvar et al., 2024

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