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Do not use in patients with known hypersensitivity to Hydroxocobalamin or cobalt

Because NAD+ activates sirtuins and PARP enzymes involved in DNA repair and cellular proliferation, there is a theoretical concern that elevating NAD+ levels in individuals with active malignancy could inadvertently support tumor growth

Dosage selection The median lethal dose (LD50) of CdCl 2 in mouth was 93.7 mg/kg 11

Even in healthy athletes, the build-up of ammonia can lead to extreme fatigue and dementia because it reduces glycogen formation and inhibits the energy cycle

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Li T, Xie R, Zhao J, Xu H, Cui Y, Sun C, Wang C, and Liu Y