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MET-097i: Limited safety data from Phase 1/2 and Phase 2b trials

This work was prompted by our earlier observation that C-terminal acylation of biased GLP-1RAs based on exendin-4 results in reduced recruitment efficacy for -arrestin and mini-G protein (Lucey et al ., 2020)

However, the relationship between diet, metabolism, and treatment is complex

Through the Fenton reaction, excess iron ions can generate ROS, which can result in lipid peroxidation and serve as the pathological foundation for ferroptosis ( In the regulatory mechanism of ferroptosis, numerous signaling pathways and molecules play crucial roles ( Figure 2 )

Y., Kruger, W