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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters
Furthermore, most studies are limited to daily sampling and thus were not designed to address rapid changes that may occur within the endogenous metabolome of the individual in response to high-dose ingestion of APAP
Both share similar gastrointestinal side effects and carry a boxed warning for thyroid C-cell tumors