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Oral therapy is generally unsuitable for pernicious anaemia or conditions affecting the terminal ileum (where B12 is absorbed), as these patients lack intrinsic factor or have damaged absorption sites

Arch Toxicol 97(10):24992574 Lv D, Fei Y, Chen H, Wang J, Han W, Cui B et al (2024) Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment

This was described by the original authors as "very surprising" and represented a categorically different selectivity profile from all previously characterised GHRP receptor agonists

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