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For weight loss, the FDA approved Wegovy HD (semaglutide 7.2 mg weekly) in March 2026

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Researchers who are eating according to a structured nutrition plan , maintaining adequate protein intake, and incorporating resistance training see significantly better outcomes than those relying on the medication alone

In short, semaglutide answers what does sustained GLP-1 activation do? while tirzepatide answers what happens when GLP-1 and GIP are engaged together? That distinction, more than any single number, is the heart of the comparison