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1 Introduction Hyperammonemia is a common complication of neonatal organic acidemia, with approximately 61.5% of patients developing hyperammonemia ( Carglumic acid, a structural analog of N-acetylglutamic acid, was granted approval in Europe in 2003 for the treatment of inherited metabolic disorders, including N-acetylglutamate synthase deficiency and organic acidemia

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The Journal of Nutrition, 2008

52 proteins were found to be common between epilepsy, oxidative stress and VPA targets (Fig