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While the exact connection between GLP-1 receptor agonists and weight loss isnt clear, there are a few ways they likely work
One recent clinical trial randomized 2301 women in five countries to high dose supplementation (4.0mg folic acid a day) from around 14 weeks gestation to delivery, but did not find a significant effect on rates of developing preeclampsia (Wen 2018)
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Approximately 5-10% of patients lose less than 5% of body weight despite adequate dosing and treatment duration
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