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For example, NAPQI, the toxic metabolite, is primarily the product of CYP2E1 metabolism, and there is evidence that younger children have a relative immaturity in CYP2E1 metabolism, which would substantially reduce the production of this toxic metabolite in infants.7 After birth, CYP2E1 protein expression and activity increases, reaching adult levels by about 1 year of age.7 The ability of the liver to metabolize acetaminophen changes with age owing to differences in activity of these key metabolic pathways
10.5665/sleep.3830 Sleep 10 BaileyC
A single freeze-thaw cycle can reduce bioactivity by 3040%
J Endocrinol Invest 11:653, 1988
If using thighs as well, add them to create a six-site rotation
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