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TBI-induced changes of systemic and microbiome metabolism In addition to the cellular pathways discussed here, TBI impacts systemic metabolism through systemic immune activation and by altering brain signaling that maintains homeostatic metabolic function [i.e

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In large-scale longer-term cardiovascular outcomes trials [47, 48, 84], long-term DPP-4 inhibition was associated with no change or a small decline in glomerular function that persisted during the entire duration of follow-up (up to 4 years)

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