doi: 10.3389/fphar.2020.566783 Received 29 May 2020 Accepted 25 November 2020 Published 17 December 2020 Volume 11 - 2020 Edited by Lyndy Joy McGaw, University of Pretoria, South Africa Reviewed by Achille Assogbadjo, University of Abomey-Calavi, Benin Pierlorenzo Pallante, Consiglio Nazionale Delle Ricerche (CNR), Italy Updates Copyright 2020 Xiao, Wang, Meng, Liang, Wang, Zhou, Wang, Luo, Gao and Zhang
Many adults suffer from B12 deficiency without realizing it, experiencing symptoms they attribute to stress, aging, or busy lifestyles
4.2 Mitochondrial ROS scavenging systems Excessive reactive oxygen species (ROS) accumulation leads to lipid peroxidation, mitochondrial membrane depolarization, cytochrome c release, caspase activation, and mitochondria-dependent apoptosis ( 2 - ), rapidly converted to hydrogen peroxide (H 2 O 2 ) by superoxide dismutases (SOD1 in cytosol/intermembrane space, SOD2 in the matrix, and SOD3 extracellularly) (Yang et al., 2020)
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PMID: 34992578