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The answer is more nuanced than a simple yes or no

J Int Soc Sports Nutr 10(1):6 [DOI] [PMC free article] [PubMed] [Google Scholar] 53.Li N, Chen S, He Y, Chen Y, Duan X, He W et al (2025) Effects of oral supplementation of beta -hydroxy-beta -methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis

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The 60-day washout recommendation leaves a gray zone between 30 and 60 days where serum clearance is likely complete but tissue depot effects remain theoretically possible