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Pyroptosis activation during ovarian tissue cryopreservation and autotransplantation can be mitigated by pyroptosis inhibitors (Wang et al., 2019), improving ovarian function

doi: 10.3389/fonc.2026.1748136 Received 18 November 2025 Revised 23 March 2026 Accepted 24 March 2026 Published 30 April 2026 Volume 16 - 2026 Edited by Pierfranco Conte, University of Padua, Italy Reviewed by Valeria Conti, University of Salerno, Italy T Mohan Viswanathan, Karpagam Academy of Higher Education, India Updates Copyright 2026 Talath, El-Tanani, Wali, Rabbani, Bhongande, Ibraheem, Avagimyan, Hoffmann, Ilias, Ispas, Viviana, Paczkowska and Rizzo

It is characterized by initial reduced blood supply to tissues (ischemia) and subsequent reoxygenation via restored blood flow (reperfusion) (71)

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